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https://www.ncbi.nlm.nih.gov/pubmed/9225114
Androgen support of lacrimal gland function. Azzarolo AM(1), Mircheff AK, Kaswan RL, Stanczyk FZ, Gentschein E, Becker L, Nassir B, Warren DW. Author information: (1)Department of Cell and Neurobiology, University of Southern California, School of Medicine, Los Angeles 90033, USA.Cited by: 113
https://link.springer.com/article/10.1007/BF02738800
Androgen support of lacrimal gland function. Abstract. The effects of dihydrotestosterone (DHT) (1 mg/kg) on biochemical parameters related to lacrimal secretion, basal tear flow rate, and pilocarpine-stimulated lacrimal gland fluid secretion, in mature ovariectomized rabbits were studied.Cited by: 113
https://link.springer.com/chapter/10.1007/978-1-4615-5359-5_11
Androgens have been shown to be responsible for the male-like morphological and functional characteristics of the gland, including larger acini, 4 greater secretion of IgA, 5 and greater production of polymeric IgA receptor, measured as secretory component (SC). 6 When female rats are treated with androgens, the morphology of the lacrimal gland ...Cited by: 13
http://europepmc.org/abstract/MED/9225114
Mar 01, 1997 · These results suggest that androgens play a major role in supporting lacrimal gland secretory function. Additionally, they suggest that estrogens may influence certain aspects of lacrimal functions, although it is not clear to what extent those actions are elicited directly or indirectly.Cited by: 113
https://www.deepdyve.com/lp/springer-journals/androgen-support-of-lacrimal-gland-function-fANb3Ct7qn
Oct 28, 2007 · Androgen support of lacrimal gland function. 2007-10-28 00:00:00 The effects of dihydrotestosterone (DHT) (1 mg/kg) on biochemical parameters related to lacrimal secretion, basal tear flow rate, and pilocarpine-stimulated lacrimal gland fluid …
https://www.sciencedirect.com/science/article/abs/pii/S0960076096001902
Of particular interest is the fact that the androgen control of IgA output by the lacrimal gland appeared to be independent of this steroid's suppression of lymphocyte infiltration in lacrimal tissue. Overall, these results show that androgen therapy enhances the functional activity of the lacrimal gland in mouse models of Sjögren's syndrome.Cited by: 128
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132553/
Androgen binding sites have been found in lacrimal tissues of male and female rats, and androgen receptor mRNA has been found in the lacrimal glands of various species, including humans. 52 Furthermore, T-containing pellets enhanced lacrimal gland function, and systemic administration suppressed lacrimal gland inflammation in mouse models of SS ...Cited by: 11
https://www.sciencedirect.com/science/article/pii/S0014483503002586
Therefore, it is believed that androgens provide trophic support of the lacrimal gland as well as meibomian gland function. The loss of androgen support results in an inability of the ocular surface to respond appropriately to environmental challenges.Cited by: 501
https://www.tearfilm.org/dewsreport/pdfs/Endocrine%20markers%20in%20the%20diagnosis%20of%20dry%20eye%20syndromes.pdf
androgens regulate numerous aspects of the lacrimal gland, including epithelial cell morphology, gene expression, protein synthesis, secretory processes and immune function.1 Indeed, androgen action appears to account for many of the sex-related differences that exist in the anatomy, molecular
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160069/
Androgens are important for providing trophic support to the lacrimal functional unit as well as creating a general anti-inflammatory environment.[33,34] Decrease in androgen levels can cause loss of the anti-inflammatory environment within the lacrimal gland. Meibomian glands are also androgen …
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