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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428377/
Aromatase, a member of the cytochrome P450 superfamily, is the enzyme responsible for key steps in the synthesis of estrogens . Aromatase is expressed in a several tissues including undifferentiated adipose fibroblasts and breast tumors, but is not expressed in mature adipocytes [9,18].Cited by: 113
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519084/
The balance between estrogen synthesis and deactivation maintains physiological estrogen homeostasis. Aromatase catalyzes the last and rate-limiting step in E2 synthesis, and aromatase regulation is a major mechanism for controlling estrogen synthesis (Bulun et al. 2005, 2009).Cited by: 30
https://en.wikipedia.org/wiki/Aromatase
Aromatase, also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is CYP19A1, a member of the cytochrome P450 superfamily (EC 1.14.14.1), which are monooxygenases that catalyze many reactions involved in steroidogenesis.Aliases: CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, …
http://pharmrev.aspetjournals.org/content/57/3/359
Sep 01, 2005 · A single gene encodes the key enzyme for estrogen biosynthesis termed aromatase, inhibition of which effectively eliminates estrogen production. Aromatase inhibitors successfully treat breast cancer and endometriosis, whereas their roles in endometrial cancer, uterine fibroids, and aromatase excess syndrome are less clear. Ovary, testis, adipose tissue, skin, hypothalamus, and …Cited by: 550
https://www.deepdyve.com/lp/wiley/aromatase-regulation-and-breast-cancer-vEVEo9Jdvg
May 01, 2001 · Aromatase regulation and breast cancer Aromatase regulation and breast cancer Reed, M. J.; Purohit, A. 2001-05-01 00:00:00 Introduction The aromatase enzyme complex is responsible for the conversion of androgens to oestrogens within the human body. The regulation and inhibition of its activity have attracted considerable research interest in recent years because of its …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695493/
The interaction between aromatase and Sf1 appears complex, and examples of aromatase expression in the absence of Sf1 are found even in mammalian models. For example, aromatase expression is a marker for undifferentiated adipose cells, but these cells do not express Sf1.Cited by: 117
https://www.nature.com/articles/s41598-017-05658-6
Jul 13, 2017 · Regulation of aromatase expression in the anterior amygdala of the developing mouse brain depends on ERβ and sex chromosome complement ... to ensure continued support, we are displaying the site ...Cited by: 11
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