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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356396/
The Bioartificial Liver Support System (BLSS) device, developed in Pittsburgh, PA, uses 70 to 120 g of primary porcine hepatocytes. The hepatocytes, mixed with 20% collagen, are housed in an extrafiber space. Whole blood is perfused through the fibers of the bioreactor after passing through an oxygenator.Cited by: 268
https://medcaretips.com/bioartificial-liver/
In most bioartificial liver support devices, the liver cells are separated from the patient’s blood or plasma by at least one membrane to provide an immunological barrier. But it also limits the exchange of substances and therefore potentially reduces the effectiveness of the system.
https://link.springer.com/protocol/10.1007%2F978-1-60761-688-7_28
Feb 10, 2010 · A variety of bioartificial liver support systems were developed to replace some of the liver’s function in case of liver failure. Those systems, in contrast to purely artificial systems, incorporate metabolically active cells to contribute synthetic and …Cited by: 27
https://clinicaltrials.gov/ct2/show/NCT03084198
Mar 20, 2017 · Procedure: hiHep Bioartificial Liver Support System Continuous treatment with the hiHep bioartificial liver support system for a minimum of 3 days to a maximum of 14 days. The subject's ultrafiltrated blood is circulated through 4 cartridges.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723496/
Apr 15, 2000 · The recent development of bioartificial liver support system containing hepatocytes is an important event in the research of the artificial liver. This system possesses the potential metabolic and synthetic functions of the liver and may provide certain nutrients and cytokines necessary for the regeneration of liver tissues[ 2 , 3 ].Cited by: 12
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