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http://pubs.acs.org/doi/abs/10.1021/ar50129a002
The use of insoluble polymer supports in general organic synthesis. ADVERTISEMENT. Log In Register. Cart ACS; ... Thioester Termini: Molecular Scale Wires with Alligator Clips. Derivation of Iterative Reaction Efficiencies on a Polymer Support. LeRoy Jones, ... THE USE OF INSOLUBLE POLYMER SUPPORTS IN GENERAL ORGANIC SYNTHESIS. C. C. LEZNOFF.
https://en.wikipedia.org/wiki/Oligonucleotide_synthesis
Oligonucleotide synthesis is the chemical synthesis of relatively short fragments of nucleic acids with defined chemical structure . The technique is extremely useful in current laboratory practice because it provides a rapid and inexpensive access to custom-made oligonucleotides of the desired sequence.
https://en.wikipedia.org/wiki/Peptide_synthesis
The established method for the production of synthetic peptides in the lab is known as solid-phase peptide synthesis (SPPS). Pioneered by Robert Bruce Merrifield, SPPS allows the rapid assembly of a peptide chain through successive reactions of amino acid derivatives on an insoluble porous support.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845543/
The chemical synthesis of proteins is now possible because of the prodigious advances in peptide synthesis that have occurred over the last century. Fischer’s 1901 synthesis of glycyl glycine is the first reported synthesis of a dipeptide and is also the first instance of the term “peptide” used to refer to a polymer of amino acids ( 48 ).Cited by: 354
https://www.protein.iastate.edu/synthesis.html
Solid phase peptide synthesis, developed by R. B. Merrifield, was a major breakthrough allowing for the chemical synthesis of peptides and small proteins. The general scheme of solid phase peptide synthesis is illustrated in Figure 1. An insoluble polymer support (resin) is used to anchor the peptide chain as each additional alpha-amino acid is ...
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