Combinatorial Chemistry And Synthesis On Solid Support

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Combinatorial Chemistry and Synthesis on Solid Support

    http://www-oc.chemie.uni-regensburg.de/OCP/ch/chv/oc22/script/CombiChem-Handout-part1.pdf
    Combinatorial Chemistry and Synthesis on Solid Support Burkhard König University of Regensburg Outline I. Solid phase synthesis 1. Polymers, resins, supports 2. Linkers 3. Analytical techniques Solid phase synthesis protocols and automatization 4. Peptide Synthesis a) Protecting groups (- CO 2H, -NH 2, side chain= Special topic: Photoremovable ...

Solid Phase Synthesis - Combinatorial chemistry

    http://www.combichemistry.com/solid_phase_synthesis.html
    Jul 25, 2018 · This resulted in the spectacular outburst of combinatorial chemistry, which profoundly changed the approach for new drugs, new catalyst or new natural discovery. The use of solid support for organic synthesis relies on three interconnected requirements: 1) A cross linked, insoluble polymeric material that is inert to the condition of synthesis;

Principles of Combinatorial Chemistry

    http://www-oc.chemie.uni-regensburg.de/OCP/ch/chv/oc22/script/002.pdf
    Combinatorial Chemistry 2.) Synthetic methods & techniques in ... ¾Split- Pool- Procedure requires a solid support Advantages: • Only few reaction vessels required • Method of choice for large libraries ... Evaluating the success of a combinatorial synthesis by

Solid supports for combinatorial chemistry - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/S1367593102003277
    Solid-phase synthesis continues to hold a dominant position in combinatorial synthesis as ever more chemistries are redeveloped on this medium and with the increasing use of supported reagents, catalysts and scavengers. The success of any solid-phase synthesis depends on the properties of the solid support in many critical ways.Cited by: 20

Synthesis of azepane scaffolds on solid support for ...

    https://www.sciencedirect.com/science/article/pii/S0040403999012472
    Enantiopure C 2-symmetric azepanes have been synthesized on solid support as scaffolds for the synthesis of peptidomimetics in combinatorial chemistry.The key step involves Rink resin as a formal equivalent of ammonia in the nucleophilic opening of L-iditol bis-epoxide.Cited by: 15

Solid-phase synthesis - Wikipedia

    https://en.wikipedia.org/wiki/Solid-phase_synthesis
    In chemistry, solid-phase synthesis is a method in which molecules are covalently bound on a solid support material and synthesised step-by-step in a single reaction vessel utilising selective protecting group chemistry. Benefits compared with normal synthesis in a liquid state include: High efficiency and throughput; Increased simplicity and speed

Williamson Ether Synthesis on Solid Support: Substitution ...

    https://pubs.acs.org/doi/10.1021/cc0000895
    Reactions of Solid-Supported Reagents and Solid Supports with Alcohols and Phenols through Their Hydroxyl Functional Group. Journal of Combinatorial Chemistry 2003, 5 (5) , 479-546. DOI: 10.1021/cc020106l.Cited by: 1

Strategy and Tactics in Combinatorial Organic Synthesis ...

    https://pubs.acs.org/doi/10.1021/ar950170u
    Synthesis of azepane scaffolds on solid support for combinatorial chemistry. Tetrahedron Letters 1999 , 40 (33) , 6005-6008. DOI: 10.1016/S0040-4039(99)01247-2.Cited by: 333

Combinatorial Chemistry authorSTREAM

    http://www.authorstream.com/Presentation/hariteja43-1369711-2003-combinatorial-chemistry/
    Mar 24, 2012 · Combinatorial Chemistry S.Sri Hari teja Siddharth Institute of Pharmacy IV year B Pharmacy Regd No- 08CR1R0043. ... combinatorial synthesis on solid support is usually carried out by using one of the following method Parallel synthesis Mix and Split method. Parallel s y nthesis.



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