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https://www.dermnetnz.org/topics/purpura/
Deficient vascular support, as in aged or sun damaged skin (senile purpura) ... The signs and symptoms of purpura vary according to the type of purpura. The following broad generalisations may be made. Petechiae are usually present in thrombocytopaenic purpura. There may be …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150945/
Apr 15, 2002 · Although the majority of the available data support a role for bradykinin, the critical question is whether bradykinin alone could account for the symptoms of patients with HAE, or other mediators are also involved. ... The increased vascular permeability in C1INH-deficient mice is …Cited by: 436
https://www.ncbi.nlm.nih.gov/pubmed/31301687
RESULTS: Vascular changes occurred in FVIII-deficient and Hypo BALB/c mice after injury with minimal effect of hemostasis correction. Increased vascular permeability was only significant in FVIII-deficient mice, who exhibited more pronounced vascular remodeling than …Author: Esther J. Cooke, Esther J. Cooke, Tine Wyseure, Jenny Y. Zhou, Srila Gopal, Chanond A. Nasamran, Kat...
https://en.wikipedia.org/wiki/Vascular_purpura
Purpura (/ ˈ p ɜːr p jʊər ə /) is a condition of red or purple discolored spots on the skin that do not blanch on applying pressure. The spots are caused by bleeding underneath the skin secondary to platelet disorders, vascular disorders, coagulation disorders, or other causes. They measure 3–10 mm, whereas petechiae measure less than 3 mm, and ecchymoses greater than 1 cm.Specialty: Dermatology, hematology
http://www.drmhijazy.com/english/chapters/chapter40.htm
Vascular purpura. Non-thrombocytopenic purpura comprises the vast majority of cases of purpura. Blood may leak as a result of: Damage to small blood vessels. Increase in the intraluminar pressure. Deficient vascular support. Bleeding may arise from a disturbance of one or more of the following mechanisms:
https://www.nature.com/articles/s41422-019-0229-5
Sep 09, 2019 · However, ectopic expression of CDS1 could not rescue vascular phenotype in CDS2-deficient zebrafish embryos either with or without vegfa OE. …Author: Wencao Zhao, Le Cao, Hanru Ying, Wenjuan Zhang, Dantong Li, Xiaolong Zhu, Wenzhi Xue, Shuang Wu, Men...
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1269-y
Apr 08, 2015 · Shb is a signaling protein downstream of vascular endothelial growth factor receptor-2 and Shb deficiency has been found to restrict tumor angiogenesis. The present study was performed in order to assess metastasis in Shb deficiency using B16F10 melanoma cells. B16F10 melanoma cells were inoculated subcutaneously on wild type or Shb +/− mice.Cited by: 10
https://www.sciencedirect.com/science/article/pii/S0024320519311178
However, our results mechanistically support the hypothesis that bone marrow-derived cells such as progenitors of myeloid origin transiently reside at vascular lesions, gain monocytic characteristics and determine the fate of vascular remodeling in a paracrine manner . Based on this hypothesis and in line with our previous investigations, TLR2 ...Author: W. Liu, J.-C. Eczko, M. Otto, R. Bajorat, B. Vollmar, J.-P. Roesner, N.-M. Wagner
https://www.nature.com/articles/nature06868
Apr 16, 2008 · To assess tumour vascular morphology, insulinomas in RIP1-Tag5 wild-type or Rgs5-deficient RIP1-Tag5 mice at 27 weeks of age were visualized after lectin perfusion using confocal microscopy (Fig ...
https://www.atsjournals.org/doi/full/10.1165/rcmb.2002-0024OC
Apr 01, 2003 · Gelsolin is a potent actin filament regulatory protein that controls cytoskeletal assembly and disassembly. Because cellular gelsolin deficiency leads to pronounced actin stress fiber formation and defective chemotaxis, and similar cytoskeletal remodeling results in endothelial barrier dysfunction, we hypothesized that gelsolin deficient mice would exhibit increased vascular permeability.Cited by: 68
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