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http://www.eurekaselect.com/69494/article
Abstract: Pharmacokinetics has been recognized as one of the elements determining the probability of success in pharmaceutical research. As a result, compounds are routinely evaluated in drug discovery for their absorption, distribution, metabolism and elimination properties.Cited by: 12
https://onlinelibrary.wiley.com/doi/book/10.1002/3527600213
The medical benefits of a drug are not only dependent on its biological effect, but also on its "life cycle" within the organism - from its absorption into the blood, distribution to tissue until its eventual breakdown or excretion by the liver and kidneys.
https://www.covance.com/services/analytical-services/drug-metabolism-and-pharmacokinetic-services.html
Partner with Covance on your drug metabolism and pharmacokinetics (DMPK) studies. Together, we will unlock your drug's metabolic and ADME properties. We have over 30 years experience providing drug metabolism support. Our senior scientists include 20+ PhDs, and more than 10% of our staff comes from large and small pharma background.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635651/
Inhibitors of CESs could be used as co-drugs to improve pharmacokinetics, efficacy, and safety profiles of clinically approved drugs where CESs are involved in drug metabolism and clearance [14, 15]. Because of the critical role of CES1 in metabolizing cholesteryl esters [ …Cited by: 2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146880/
Apr 12, 2018 · Drug metabolism as a discipline plays an important role in drug discovery and development and the effects of drug metabolism on pharmacokinetics (PK), pharmacodynamics (PD), and safety should be carefully considered. This communication provides an overview of common strategies in the area of drug ...Cited by: 15
https://www.sciencedirect.com/science/article/pii/S2211383517306767
Drug metabolism as a discipline plays an important role in drug discovery and development and the effects of drug metabolism on pharmacokinetics (PK), pharmacodynamics (PD), and safety should be carefully considered.Cited by: 15
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527645763
Apr 04, 2012 · He worked for Pfizer for 24 years in the Pharmacokinetics, Dynamics and Metabolism Department contributing scientific leadership to the drug metabolism and pharmacokinetic evaluations on many drug discovery and development projects across a range of therapeutic areas including cardiovascular, allergy and respiratory, anti-infectives and sexual ...
https://www.amazon.com/Pharmacokinetics-Metabolism-Design-Dennis-Smith/dp/3527329544
Pharmacokinetics and Metabolism in Drug Design 3rd Edition. ... If you are a seller for this product, would you like to suggest updates through seller support? Start reading Pharmacokinetics and Metabolism in Drug Design on your Kindle in under a minute. Don't have a Kindle?Author: Dennis A. Smith
https://www.labiotech.eu/sponsored/dmpk-metabolism-pharmacokinetics-toxicity-drug-design-evotec/
The Importance of Metabolism, Pharmacokinetics and Toxicity in Drug Design Sponsored Post - 22/01/2018 9 mins - Sponsored Growing awareness and knowledge of the chemical space, which is required to engage contemporary drug targets, is steadily increasing the complexity of drug development and challenging the paradigms of the industry.
https://www.worldpreclinicalcongress.com/Drug-Metabolism-Pharmacokinetics/
8:50 Intracellular Unbound Drug Concentrations in Presence of Metabolism and Transport. Priyanka Kulkarni, PhD, Scientist, Pharmacokinetics and Drug Metabolism, Amgen, Inc. Accurate prediction of target activity of a drug and rational design of dosing regimen requires knowledge of drug concentration at …
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