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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495871/
Dobutamine is the inotrope endorsed by the sepsis guidelines based largely on the trial comparing early goal-directed therapy (EGDT) versus standard care in sepsis. 1 Rivers et al. demonstrated that a protocolized approach to early resuscitation could significantly reduce 28-day mortality in patients presenting with severe sepsis or septic shock.Cited by: 4
https://www.ncbi.nlm.nih.gov/books/NBK385327/
Sepsis management consists of a bundle of actions to be taken as soon as possible after diagnosis. Inotropic agents, which alter heart muscle contractions, and vasopressors, which cause the constriction of blood vessels, are important parts of sepsis treatment. Some agents have characteristics of both.
http://journals.lww.com/ccmjournal/Abstract/2004/11001/Vasopressor_and_inotropic_support_in_septic_shock_.4.aspx
Objective: In 2003, critical care and infectious disease experts representing 11 international organizations developed management guidelines for vasopressor and inotropic support in septic shock that would be of practical use for the bedside clinician, under the auspices of the Surviving Sepsis Campaign, an international effort to increase awareness and to improve outcome in severe sepsis.
http://www.uptodate.com/contents/evaluation-and-management-of-suspected-sepsis-and-septic-shock-in-adults
In a retrospective series of 234 patients with septic shock, among several vasopressor agents added to norepinephrine (dobutamine, dopamine, phenylephrine, vasopressin), inotropic support with dobutamine was associated with a survival advantage (epinephrine was not studied) .
http://www.uptodate.com/contents/use-of-vasopressors-and-inotropes
Oct 31, 2018 · Practice parameters for hemodynamic support of sepsis in adult patients in sepsis. Task Force of the American College of Critical Care Medicine, Society of Critical Care Medicine. Crit Care Med 1999; 27:639. Moran JL, O'Fathartaigh MS, Peisach AR, et al. Epinephrine as an inotropic agent in septic shock: a dose-profile analysis.
https://www.researchgate.net/publication/316843958_Validation_of_the_Vasoactive-Inotropic_Score_in_Pediatric_Sepsis
Objectives: To assess the validity of Vasoactive-Inotropic Score as a scoring system for cardiovascular support and surrogate outcome in pediatric sepsis.
https://www.researchgate.net/publication/236036399_Inotropic_support_in_septic_shock
Inotropic support in septic shock? ... The ability of catecholamine inotropic drugs to stimulate bacterial proliferation and biofilm formation may be an aetiological factor in the development of ...
https://www.medscape.com/answers/168402-27450/what-is-the-role-of-inotropic-therapy-in-sepsisseptic-shock
Oct 24, 2019 · Although myocardial performance is altered during sepsis and septic shock, cardiac output generally is maintained in patients with volume-resuscitated sepsis. ... the role of inotropic therapy is ...
https://reference.medscape.com/medline/abstract/15542956
OBJECTIVE: In 2003, critical care and infectious disease experts representing 11 international organizations developed management guidelines for vasopressor and inotropic support in septic shock that would be of practical use for the bedside clinician, under the auspices of the Surviving Sepsis Campaign, an international effort to increase ...
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