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https://link.springer.com/article/10.1007%2Fs10404-006-0095-6
May 20, 2006 · Microchannel bioreactors for bioartificial liver support. Abstract. An extracorporeal bioartificial liver (BAL) device containing viable hepatocytes has the potential to provide temporary hepatic support to liver failure patients, serving as a bridge to …Cited by: 8
https://www.deepdyve.com/lp/springer-journals/microchannel-bioreactors-for-bioartificial-liver-support-gHHlcaX6n3
May 20, 2006 · Read "Microchannel bioreactors for bioartificial liver support, Microfluids and Nanofluids" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649611/
The fact that liver failure constitutes a life-threatening condition and can, in most cases, only be overcome by orthotopic liver transplantation, lead to the development of various artificial and bioartificial liver support devices. While artificial systems are based on the principles of adsorption ...
http://onlinelibrary.wiley.com/doi/10.1002/bit.20463/abstract
Apr 15, 2005 · An extracorporeal bioartificial liver device has the potential to provide temporary hepatic support for patients with liver failure. Our goal was to optimize the flow environment for the cultured hepatocytes in a flat‐plate bioreactor, specifically focusing on oxygen delivery using high medium flow rates while reducing the detrimental effects of the resulting shear stresses.
https://www.sciencedirect.com/topics/nursing-and-health-professions/bioartificial-liver
Bioartificial Liver Support Bioartificial liver (BAL) systems rely on the use of hepatocytes (human or nonhuman) to perform detoxification and secretion of liver-synthesized factors. The selection of the ideal cell source and the design of more sophisticated bioreactors are the main issues in this field of research.
https://www.sciencedirect.com/topics/medicine-and-dentistry/bioartificial-liver-device
Kjaergard and colleagues performed a systematic review of artificial and bioartificial liver support devices for the treatment of acute and acute-on-chronic liver failure. 95 They identified 12 randomized trials with 483 patients. Overall, support systems had no significant effect on mortality compared with standard therapy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356396/
The Bioartificial Liver Support System. The Bioartificial Liver Support System (BLSS) device, 80,81 developed in Pittsburgh, PA, uses 70 to 120 g of primary porcine hepatocytes. The hepatocytes, mixed with 20% collagen, are housed in an extrafiber space.Cited by: 268
https://www.researchgate.net/publication/11958192_Bioartificial_Liver_Support
Bioartificial liver support is a promising technology, and the results of current and planned studies are awaited with great interest. Discover the world's research 15+ million members
http://journals.lww.com/asaiojournal/Fulltext/2001/09000/Safety_Observations_in_Phase_I_Clinical_Evaluation.15.aspx
A Phase I clinical safety evaluation of the Excorp Medical, Inc, Bioartificial Liver Support System (BLSS) is in progress. Inclusion criteria are patients with acute liver failure of any etiology, presenting with encephalopathy deteriorating beyond Parson’s Grade 2.
https://onlinelibrary.wiley.com/doi/10.1046/j.1525-1594.2001.025002119.x
Abstract: A mathematical model was developed to predict oxygen transport in a hollow fiber bioartificial liver device. The model parameters were taken from the HepatAssist 2000 device, a plasma perfused hollow fiber cartridge with primary hepatocytes seeded in the extracapillary space.Cited by: 87
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