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http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1999.tb08516.x/abstract
ABSTRACT: Preclinical safety and efficacy evaluation of a novel bioartificial liver support system (BLSS) was conducted using a d-galactosamine canine liver failure model. The BLSS houses a suspension of porcine hepatocytes in a hollow fiber cartridge with the hepatocytes on one side of the membrane and whole blood flowing on the other.
https://www.academia.edu/6965318/Novel_Bioartificial_Liver_Support_System_Preclinical_Evaluation
ABSTRACT: Preclinical safety and efficacy evaluation of a novel bioartificial liver support system (BLSS) was conducted using a d-galactosamine canine liver failure model. The BLSS houses a suspension of porcine hepatocytes in a hollow fiber
https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.1999.tb08516.x
ABSTRACT: Preclinical safety and efficacy evaluation of a novel bioartificial liver support system (BLSS) was conducted using a d‐galactosamine canine liver failure model. The BLSS houses a suspension of porcine hepatocytes in a hollow fiber cartridge with the hepatocytes on one side of the membrane and whole blood flowing on the other.Cited by: 96
https://www.sciencedirect.com/science/article/pii/S1072751502012772
Development of bioartificial livers for support of patients with acute liver failure requires meaningful preclinical evaluation before clinical trials. STUDY DESIGN: Complete results from preclinical safety and efficacy evaluation of the Excorp Medical Bioartificial Liver Support System (BLSS) using a D-galactosamine (D-gal) canine liver ...Cited by: 32
https://onlinelibrary.wiley.com/doi/full/10.1034/j.1600-6143.2002.20311.x
The Excorp Medical Bioartificial Liver Support System (BLSS), which is the subject of this report, is the most recent system to enter a Phase I/II clinical safety evaluation (10, 11). Like the Gerlach BELS, the BLSS uses cultured, primary porcine hepatocytes.Cited by: 151
https://ui.adsabs.harvard.edu/abs/1999NYASA.875..340P/abstract
Jun 01, 1999 · Not Available adshelp[at]cfa.harvard.edu The ADS is operated by the Smithsonian Astrophysical Observatory under NASA Cooperative Agreement NNX16AC86ACited by: 96
https://www.researchgate.net/publication/11278816_First_Clinical_Use_of_a_Novel_Bioartificial_Liver_Support_System_BLSS
The first clinical use of the Excorp Medical Bioartificial Liver Support System (BLSS) in support of a 41-year-old African-American female with fulminant hepatic failure is described.
https://health.usnews.com/doctors/david-kramer-191230
Novel bioartificial liver support system: preclinical evaluation Patzer JF II, Mazariegos GV, Lopez R, Molmenti E, Gerber D, Riddervold F, Khanna A, Yin WY, Chen Y, Scott VL, Aggarwal S, Kramer D ...
https://link.springer.com/protocol/10.1007%2F978-1-60761-688-7_28
Abstract. A variety of bioartificial liver support systems were developed to replace some of the liver’s function in case of liver failure. Those systems, in contrast to purely artificial systems, incorporate metabolically active cells to contribute synthetic and regulatory functions as well as detoxification.
https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/liver-support-systems
Liver spheroids have a potential use in this field, directly transplanted or employed in hybrid and bioartificial liver support systems (Fig. 62.2) [70–72]. In 2005, Gan et al. explored the role of a spheroid-based hybrid artificial liver support system (HALSS) for treatment of severe liver failure.
http://ipn.academia.edu/RLopez
ABSTRACT: Preclinical safety and efficacy evaluation of a novel bioartificial liver support system (BLSS) was conducted using a d-galactosamine canine liver failure model. The BLSS houses a suspension of porcine hepatocytes in a hollow fiber cartridge with the hepatocytes on one side of the membrane and whole blood flowing on the other.
https://www.researchgate.net/publication/11159914_Preclinical_evaluation_of_the_Excorp_Medical_Inc_Bioartificial_Liver_Support_System
Preclinical evaluation of the Excorp Medical, Inc, Bioartificial Liver Support System Article in Journal of the American College of Surgeons 195(3):299-310 · October 2002 with 54 Reads
https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/lt.20446
Jul 20, 2005 · By incorporating a reservoir within the hepatocyte compartment, our novel BAL system can support a significantly greater numbers of hepatocytes than using a hollow fiber cartridge alone, as in most first‐generation systems. 20-22 The purpose of this study was to characterize the influence of oscillation frequency, cell density, and storage ...
https://www.nature.com/articles/s41598-017-03424-2
Jun 19, 2017 · Functional Evaluation of a Bioartificial Liver Support System Using Immobilized Hepatocyte Spheroids in a Porcine Model of Acute Liver Failure Skip to main content Thank you for visiting nature.com.
http://journals.lww.com/asaiojournal/Fulltext/2001/09000/Safety_Observations_in_Phase_I_Clinical_Evaluation.15.aspx
A Phase I clinical safety evaluation of the Excorp Medical, Inc, Bioartificial Liver Support System (BLSS) is in progress. Inclusion criteria are patients with acute liver failure of any etiology, presenting with encephalopathy deteriorating beyond Parson’s Grade 2.
https://www.deepdyve.com/lp/elsevier/preclinical-evaluation-of-the-excorp-medical-inc-bioartificial-liver-8RJSYeQth5
Sep 01, 2002 · Read "Preclinical evaluation of the Excorp Medical, Inc, bioartificial liver support system, Journal of the American College of Surgeons" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.nature.com/articles/cr20166
Jan 15, 2016 · In vitro evaluation of a novel bioreactor based on an integral oxygenator and a spirally wound ... Novel bioartificial liver support system: preclinical evaluation. ... Pivotal preclinical trial ...
https://link.springer.com/chapter/10.1007/978-94-010-0159-5_38
Stange J, Hassanein TI, Mehta R, Mitzner SR and Bartlett RH. The molecular adsorbents recycling system as a liver support system based on albumin dialysis: a summary of preclinical investigations, prospective, randomized, controlled clinical trial, and clinical experience from 19 centers. Artif Organs 2002;26:103–110. PubMed CrossRef Google ...
https://www.journalacs.org/article/S1072-7515(02)01277-2/fulltext
BACKGROUND:Acute liver failure has no medically recognized effective therapy other than orthotopic liver transplantation. Development of bioartificial livers for support of patients with acute liver failure requires meaningful preclinical evaluation before clinical trials.STUDY DESIGN:Complete results from preclinical safety and efficacy evaluation of the Excorp Medical Bioartificial Liver ...
https://journals.lww.com/asaiojournal/pages/articleviewer.aspx?year=2002&issue=05000&article=00005&type=Fulltext
The ramifications of using whole blood or plasma for perfusion of an hepatocyte containing bioartificial liver bioreactor in which the hepatocytes are separated by a membrane or other physical barrier from the perfusate stream on the rate of change of patient blood concentrations are explored through dynamic modeling of whole blood perfusion as a two compartment system (patient tissue and ...
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