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https://www.researchgate.net/profile/Russell_Taichman/publication/6574477_Osteoblasts_support_B-lymphocyte_commitment_and_differentiation_from_hematopoietic_stem_cells/links/00b7d528f50a09ea99000000.pdf?origin=publication_detail
purified primary murine OB also support the differentiation of primitive hematopoietic stem cells through lymphoid commitment and subsequent differentiation to all stages of B cell precursors …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762579/
Zhu et al. further demonstrated that calvarial osteoblasts in culture could support the full differentiation program of hematopoietic stem/progenitor cells into the B lymphocyte lineage, confirming a direct interaction between osteoblastic cells and B cell precursors .Cited by: 23
http://europepmc.org/abstract/MED/17227831
Jun 01, 2007 · Previous studies had shown that osteoblasts (OBs) support hematopoietic stem cell (HSC) proliferation and myeloid differentiation. We now find that purified primary murine OBs also support the differentiation of primitive hematopoietic stem cells through lymphoid commitment and subsequent differentiation to all stages of B-cell precursors and mature B cells.Cited by: 339
https://www.researchgate.net/publication/6574477_Osteoblasts_support_B-lymphocyte_commitment_and_differentiation_from_hematopoietic_stem_cells
We now find that purified primary murine OBs also support the differentiation of primitive hematopoietic stem cells through lymphoid commitment and subsequent differentiation to all stages of B ...
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.160007
Hematopoietic stem cell differentiation occurs in direct proximity to osteoblasts within the bone marrow cavity. Despite this striking affiliation, surprisingly little is known about the precise cellular and molecular impact of osteoblasts on the bone marrow microenvironment.Cited by: 245
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349388/
Osteoblasts, stromal cells, and endothelial cells then populate the vascularized bone marrow and produce chemokines and growth factors that recruit and maintain hematopoietic stem cells . Understanding the cellular and molecular cross talk in bone marrow microenvironment controlling bone formation and hematopoiesis is a rapidly growing area of research given the important implications for bone therapy…Cited by: 11
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