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https://www.onlinebiologynotes.com/plasmodium-falciparum-morphology-life-cycle-pathogenesis-and-clinical-disease/
Jul 29, 2018 · The process of formation of sporozoite is called sporogony. Anopheles mosquitoes during its blood meal from infected person, ingest both the sexual and asexual forms of parasite along with blood. Mature sexual form ie.
https://jcs.biologists.org/content/joces/121/11/1937.full.pdf
membrane. The invaded merozoite rapidly develops into the ring stage, which is marked by low metabolic activity. After ~20 hours, the parasite enters the trophozoite stage, which is marked by robust protein, RNA and DNA synthesis and the commencement of hemoglobin digestion. DNA replication occurs in the schizont stage,Cited by: 75
https://www.inspirenignite.com/anna-university/molecular-pathogenesis-of-infectious-diseases-biotech-6th-sem-syllabus-for-b-tech-2017-regulation-anna-univ-professional-elective-iii/
Dec 10, 2019 · Shigella: Entry, macrophage apoptosis, induction of macropinocytosis, uptake by epithelial cells, intracellular spread, inflammatory response, tissue damage Plasmodium: Life cycle, erythrocyte stages, transport mechanism and processes to support the rapidly growing schizont, parasitiparous vacuoles, and knob protein transport, Antimalarials based on transport processes.
https://quizlet.com/62475585/plasmodium-life-cycle-and-basic-features-flash-cards/
Sporozoites injected during mosquito feedig -> invade liver cells -> exoerthyrocytic shizogony (merozoites) -> merozoites invade RBCs -> repeated erthrocytic shizogony -> gametes infective for mosquito -> fusion of gametes in gut -> sporogony on gut wall in hemocoel -> sporozoites invade salivary glands. Transmission of Plasmodium.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007624/
Artemisinins: Front-line Antimalarials under Threat. In 2015 the malaria parasite Plasmodium falciparum killed over 400 000 people, most of whom were children under the age of five [].Thus it is of acute concern that resistance to the artemisinin derivatives (ARTs, see Glossary), the first-line drug class used to treat malaria, emerged several years ago, and is now evident in six countries in ...Cited by: 111
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981233/
Although mitochondrial electron transport is a validated target of the antimalarial drug atovaquone, the molecular details underlying parasite demise are unclear. We have shown that a critical function of mitochondrial electron transport in blood-stage Plasmodium falciparum is to support pyrimidine biosynthesis.Cited by: 62
https://www.sciencedirect.com/science/article/pii/S1471489218300250
Artemisinin-based combination therapies (ACTs) are frontline, fast acting drugs that have been key to reducing the malaria burden and deaths. However, P. falciparum resistance to artemisinins and ACTs has emerged, threatening global malaria control and elimination.Cited by: 11
https://en.wikipedia.org/wiki/Quartan_ague
Plasmodium malariae is a parasitic protozoa that causes malaria in humans. It is one of several species of Plasmodium parasites that infect humans including Plasmodium falciparum and Plasmodium vivax which are responsible for most malarial infection. While found worldwide, it is a so-called "benign malaria"...Clade: TSAR
https://quizlet.com/15937155/plasmodium-flash-cards/
sporozoites in Anopheles saliva are injected into another intermediate host; within 1 hour attach to and invade hepatocytes (circumsporozoite protein); exoerythrocytic schizogony: 2K-40K daughter cells each; after 1-2 wks hepatocyte ruptures; Erythrocytic phase: merozoite binds a specific RBC receptor and is slowly endocytosed; schizont forms…
https://www.malariasite.com/life-cycle/
Schizogony in the Human Host: Man is the intermediate host for malaria, wherein the asexual phase of the life cycle occurs. The sporozoites inoculated by the infested mosquito initiate this phase of the cycle from the liver, and the latter part continues within the red blood cells, which results in the various clinical manifestations of the disease.
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