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https://www.drugs.com/drug-class/inotropic-agents.html
Inotropic agents are a group of medicines that affect the contraction of the heart muscle. Technically, inotropes can be divided into positive inotropes, which stimulate and increase the force of contraction of the heart muscle, and negative inotropes, which weaken the force of muscular contractions, decreasing how hard the heart has to work.
https://www.texasheart.org/heart-health/heart-information-center/topics/inotropic-agents/
Inotropic agents, or inotropes, are medicines that change the force of your heart's contractions. Positive inotropes strengthen the force of the heartbeat. Negative inotropes weaken the force of the heartbeat. Both kinds are used in the treatment of many different cardiovascular conditions.
https://healthjade.net/inotropic/
Positive inotropic drugs can increase blood flow throughout your body and reduce swelling in your hands and ankles. Positive inotropic agents used for increasing cardiac contractility act in different ways. The following is a brief description of those positive inotropic agents employed frequently in heart failure.
https://www.pharmaceutical-journal.com/learning/learning-article/use-of-inotropes-in-critical-care/11049283.fullarticle
Positive inotropes increase the force of contraction of the heart, whereas negative inotropes weaken it. ... It is sometimes used for bradycardic patients requiring inotropic support. Noradrenaline. Because noradrenaline acts primarily via a 1 receptors, it is usually used as a vasopressor (increasing SVR to maintain MAP) rather than an ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898603/
Jan 01, 2012 · Positive inotropes in heart failure: a review article. ... patients requiring inotropic support were excluded. Milrinone therapy was associated with significant increases in hypotension, requiring intervention and atrial arrhythmias, ... Inotropic agents used in heart failure, ...Cited by: 1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691094/
Dec 04, 2015 · Long-term inotropic therapy should be offered in selected patients. A detailed conversation with the patient and family shall be held, including a discussion on the risks and benefits of use of inotropes. Chronic heart failure patients awaiting heart transplants are candidates for intravenous inotropic support until the donor heart becomes ...Cited by: 30
https://www.uptodate.com/contents/inotropic-agents-in-heart-failure-with-reduced-ejection-fraction
May 25, 2018 · Those with HF with preserved ejection fraction (HFpEF; also known as diastolic HF) do not need inotropic support, and the myocardial effects of these agents may be detrimental in such patients. The efficacy of acute intravenous inotropic support is well established in patients with severe myocardial systolic dysfunction.
https://www.thecardiologyadvisor.com/home/decision-support-in-medicine/cardiology/interventional-pharmacology-inotropes-and-vasopressors/
The hemodynamic actions of milrinone result from a combination of inotropic and vasodilating properties. Milrinone exerts positive inotropic actions by inhibiting PDE-3 in cardiac myocytes. PDE inhibition reduces the breakdown of intracellular cAMP, thereby enhancing calcium delivery and resulting in increased contractility.
https://medical-dictionary.thefreedictionary.com/inotropic
inotropic: [ in″o-trop´ik ] affecting the force of muscular contractions.
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