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https://www.sciencedirect.com/topics/chemistry/solid-phase-chemistry
In solid-phase chemistry, the starting material and product of a reaction are bound to a solid support and the reagents are in solution. In solution-phase chemistry, the starting material and product are in solution and either reagents or reactant scavengers are frequently bound to solid support.
https://tricliniclabs.com/index.html
Leaders in solid-state chemical analysis and development Leverage more than three decades of industry leading experience in materials characterization, solid-form screening and development, method development, and intellectual property support.
https://en.wikipedia.org/wiki/Solid-phase_synthesis
In chemistry, solid-phase synthesis is a method in which molecules are covalently bound on a solid support material and synthesised step-by-step in a single reaction vessel utilising selective protecting group chemistry. Benefits compared with normal synthesis in a liquid state include: High efficiency and throughput Increased simplicity and speed The reaction can be driven to completion and high yields …
http://www.combichemistry.com/solid_phase_synthesis.html
Jul 25, 2018 · Merrifield developed a series of chemical reactions that can be used to synthesise proteins. The direction of synthesis is opposite to that used in the cell. The intended carboxy terminal amino acid is anchored to a solid support. Then, the next amino acid is coupled to the first one.
https://www.chem.uzh.ch/dam/jcr:ffffffff-9520-0a4a-ffff-ffffe2893de1/lecture_5-6.pdf
Chemical Synthesis of Peptides and Proteins: Monitoring Coupling Reaction The identities of PG, LG, R1 and R2, and even the solid support can have a dramatic effect on the reaction rate and yield.
https://www.sigmaaldrich.com/technical-documents/articles/biology/dna-oligonucleotide-synthesis.html
The product is the solid-support-linked nucleoside with an acetylated 5'-OH (pyridine maintains a basic pH thereby preventing detritylation of the phosphoramidite monomer by the free acetate / acetic acid).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845543/
Solid-phase peptide synthesis alone has enabled the total chemical synthesis of some proteins. Since the pioneering work of Merrifield, proteins that contain as many as 166 amino acid residues have been synthesized in this fashion ( 95 ).Cited by: 354
https://bmcchembiol.biomedcentral.com/articles/10.1186/1472-6769-3-1
May 13, 2003 · Cleavage of DNA product from silica can be done as per the instructions of the commercial silica product or our described conditions. As the solid-phase chemical cleavage reactions are very convenient in terms of manipulation and purity of the products, the silica solid support is highly recommended for any chemical modification reactions on DNA.Cited by: 13
https://en.wikipedia.org/wiki/Oligonucleotide_synthesis
Oligonucleotide synthesis is the chemical synthesis of relatively short fragments of nucleic acids with defined chemical structure . The technique is extremely useful in current laboratory practice because it provides a rapid and inexpensive access to custom …
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