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http://www-oc.chemie.uni-regensburg.de/OCP/ch/chv/oc22/script/CombiChem-Handout-part1.pdf
IV. Combinatorial Chemistry 1. Library synthesis a) in solution, parallel synthesis b) on solid support c) split and combine, one bead one compound 2. Deconvolution and Tagging 3. Dynamic combinatorial Chemistry and virtual libraries Outline V. Diversity oriented synthesis (DOS) Principle and examples Molecular complexity VI. Complexity ...
https://www.sciencedirect.com/science/article/pii/S1367593102003277
Combinatorial chemistry now plays an important role in the lead discovery and hit optimisation processes in the pharmaceutical world as well as in other areas of discovery chemistry. Solid-phase synthesis continues to hold a dominant position in combinatorial synthesis as ever more chemistries are redeveloped on this medium and with the increasing use of supported …Cited by: 20
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1386-2073&volume=12&issue=7&spage=723
These methods of solid-phase combinatorial chemistry have been recently supported by introduction of solid-supported reagents and scavenger resins. The first part of this review discusses the general premises of combinatorial chemistry and some methods used in the design of primary and focused combinatorial libraries.Cited by: 9
https://pubs.acs.org/doi/10.1021/cr980040%2B
May 06, 2000 · Combinatorial Syntheses of Five-Membered Ring Heterocycles Using Carbon Disulfide and a Solid Support. Journal of Combinatorial Chemistry 2010, 12 (4) , 393-409. DOI: 10.1021/cc100049u. Pallavi Sharma and John E. Moses.Cited by: 593
http://www.combichemistry.com/solid_phase_synthesis.html
Jul 25, 2018 · This resulted in the spectacular outburst of combinatorial chemistry, which profoundly changed the approach for new drugs, new catalyst or new natural discovery. The use of solid support for organic synthesis relies on three interconnected requirements: 1) A cross linked, insoluble polymeric material that is inert to the condition of synthesis;
https://www.sciencedirect.com/science/article/pii/S0040403999012472
Enantiopure C 2 -symmetric azepanes have been synthesized on solid support as scaffolds for the synthesis of peptidomimetics in combinatorial chemistry. The key step involves Rink resin as a formal equivalent of ammonia in the nucleophilic opening of L-iditol bis-epoxide.Cited by: 15
http://www-oc.chemie.uni-regensburg.de/OCP/ch/chv/oc22/script/002.pdf
Basic idea of combinatorial chemistry: ¾Preparation of a large number of different compounds at the same time ¾High throughput- screening provides the most promising substances Combinatorial Chemistry as a valuable tool in drug discovery and material science
https://www.slideshare.net/naresh2231989/combinatorial-chemistry-1
Sep 29, 2013 · •Combinatorial Chemistry is a new method developed by academics and researchers to reduce the time and cost of producing effective, marketable and competitive new drugs. • Scientists use Combinatorial Chemistry to create large numbers of molecules that can be detected efficiently.
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