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https://www.biosyn.com/tew/solid-phase-peptide-synthesis.aspx
The basic concept in solid phase peptide synthesis is the step-wise construction of a peptide chain attached to an insoluble polymeric support (see Figure 1. for general synthesis scheme). Figure 1: General Scheme for Solid Phase Peptide Synthesis. This approach permits unreacted reagents to be removed by washing without loss of product.
https://www.beilstein-journals.org/bjoc/articles/13/206
Peptide synthesis: ball-milling, in solution, or on solid support, what is the best strategy? While presenting particularly interesting advantages, peptide synthesis by ball-milling was never compared to the two traditional strategies, namely peptide syntheses in solution and on solid support (solid-phase peptide synthesis, SPPS).
https://pubs.rsc.org/en/content/articlelanding/2014/ra/c4ra02458c
The solid-phase approach is the best alternative to synthesize these peptides rapidly and in high amounts. The key aspects that need to be considered when performing a peptide synthesis in solid phase of these molecules are discussed. You have access to …Cited by: 78
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564544/
In the early 1960s, Merrifield proposed the use of a polystyrene-based solid support for peptide synthesis. Peptides could be assembled stepwise from the C to N terminus using N α -protected amino acids. SPPS of a tetrapeptide was achieved by using Cbz as an α-amino-protecting group,...Cited by: 20
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