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https://www.sciencedirect.com/science/article/pii/S004040390078806X
We describe a general method for the solid-phase synthesis of cyclic peptides containing an Asp (7) residue in their sequence. Synthesis is performed starting from the Asp residue linked to PAM resin (8) through the carboxylic function and protected as fluorenylmethyl ester on the a-carboxylic group.Cited by: 138
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1399-3011.1990.tb00255.x
In order to mimic a well‐known loop structure (site A) of the hemagglutinin of influenza virus, a series of cyclic peptides derived from thc region 139–147 were synthesized. The lactam analogs cyclised between the N‐terminus Cys 139 and the β‐carboxyl of aspartic acid 148 (small loop) or the ENHZ of lysine 148 via succinimidyl linker (large loop) were synthesized by the solid phase method.Cited by: 60
https://www.nature.com/articles/nprot.2011.450
Feb 09, 2012 · Abstract. This protocol presents a detailed description of the synthesis of N -methylated cyclic peptides. N -methylation is a powerful technique to modulate the physicochemical properties of peptides by introducing one or more methyl groups into the peptidic amide bonds. Together with peptide cyclization, this procedure confers unprecedented...Cited by: 106
http://onlinelibrary.wiley.com/doi/10.1002/psc.2758/abstract
May 19, 2015 · Synthesis of ‘head‐to‐tail’ cyclized peptides on solid support using a chelating amide as new orthogonal protecting group. Correspondence to: Willi Bannwarth, Organische Chemie, Universität Freiburg, Albertstr. 21, 79104 Freiburg, Germany.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564544/
In the early 1960s, Merrifield proposed the use of a polystyrene-based solid support for peptide synthesis. Peptides could be assembled stepwise from the C to N terminus using N α -protected amino acids. SPPS of a tetrapeptide was achieved by using Cbz as an α-amino-protecting group,...Cited by: 20
https://www.jove.com/video/53589/development-backbone-cyclic-peptide-library-as-potential
The general principle for peptide synthesis on solid support is presented in Figure 1. The initial amino acid, masked by a temporary protecting group on the N-α-terminus, is loaded onto the resin from the C-terminus. A semi-permanent protecting group to mask the side chain is also used if …
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