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https://www.obgproject.com/2018/07/18/acog-guidance-on-thrombophilia-in-pregnancy/
Pregnancy is a well-known hypercoagulable state and inherited thrombophilias can further increase the risk for maternal venous thromboembolism (VTE). The ACOG recommendations (July 2018) address the different thrombophilias as well as associations with possible adverse pregnancy outcomes. Who to Screen; What to Include in the Screening Panel
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC305329/
Nov 14, 2003 · Pregnancy is a hypercoagulable state, and women with thrombophilia are at increased risk for thrombosis during pregnancy and adverse maternal and fetal sequelae [ 98 ]. The hemostatic system plays an important role in the success of pregnancy and the process of …Cited by: 198
https://www.acog.org/Womens-Health/Thromboembolism-and-Inherited-Thrombophilias-in-Pregnancy
Centers for Disease Control and Prevention: Venous Thromboembolism (Blood Clots) and Pregnancy This resource, published by the Centers for Disease Control and Prevention, includes information for pregnant women on the prevention of blood clots. The CDC also funded the Stop the Clot campaign which includes several educational tools for pregnant women.
https://www.mdedge.com/obgyn/article/62513/thrombophilia-pregnancy-whom-screen-when-treat
Thrombophilia has been widely investigated—and that may be one of the main challenges in detecting and managing it during pregnancy: Numerous studies have yielded different estimates of the incidence of various clotting disorders in pregnancy—itself a hypercoagulable state—and conflicting screening and prevention recommendations.
https://www.uptodate.com/contents/inherited-thrombophilias-in-pregnancy#!
INTRODUCTION. Inherited thrombophilias are genetic conditions that increase the risk of thromboembolic disease. During pregnancy, the thrombogenic potential of these inherited disorders is enhanced because of the hypercoagulable state produced by normal pregnancy-associated physiologic changes in several coagulation factors [] (see "Maternal adaptations to pregnancy: Cardiovascular …
https://www.sciencedirect.com/science/article/pii/S1521693411001519
Even after a pregnancy loss, inherited thrombophilia has apparently no effect on the outcome of the next pregnancy. 21 Analysis leads to an increasing number of positive results, which could prompt a request for genetic counselling. In 2008, data from early pregnancy units across the country were collected from routine heritable thrombophilia investigations in women who had experienced recurrent miscarriages.Cited by: 32
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614687/
The link between thrombophilia and certain pathologies of pregnancy may be an inadequate feto-placental circulation . Kupferminc et al . ( 3 ), showed a further evidence of inherited and acquired thrombophilias in relation to adverse pregnancy outcome, by means of a study on Israeli women with serious pregnancy complications compared with healthy pregnant women.Cited by: 5
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916273/
Jan 27, 2014 · The association between thrombophilia and recurrent pregnancy loss (RPL) has become an undisputed fact. Thorombophilia creates a hypercoaguable state which leads to arterial and/or venous thrombosis at the site of implantation or in the placental blood vessels.Cited by: 5
https://www.bmj.com/content/bmj/359/bmj.j4452.full.pdf
Abstract Objective To provide evidence to support updated guidelines for the management of pregnant women with hereditary thrombophilia in order to reduce the risk of a first venous thromboembolism (VTE) in pregnancy.Cited by: 20
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