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https://www.mypcnow.org/fast-fact/management-of-respiratory-failure-in-als/
The use of oxygen at night without ventilatory assistance may not be sufficient for many patients with advanced ALS with life prolonging goals of care, as oxygen desaturation and chronic hypercapnia may lead to suppression of respiratory drive during sleep. During the day bi-level support can be used to alleviate respiratory muscle fatigue.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361018/
Nov 01, 2013 · In ALS, early intervention with non-invasive ventilatory support is beneficial to preserve the quality of life, and prolong survival (Mustfa et al., 2006 ; Lechtzin et al., 2007). Invasive intervention by tracheostomy and mechanical ventilation can extend survival, but require extensive management of ventilatory support.Cited by: 26
https://alsnewstoday.com/2016/09/22/respiratory-support-in-ALS-patients-may-decrease-quality-of-life
Sep 22, 2016 · Most patients with amyotrophic lateral sclerosis (ALS) develop respiratory problems in the advanced stage of their disease and are put on chronic ventilator support to improve their symptoms. Now a new study shows that despite improved respiration, the patients’ quality of life may worsen over time.
http://www.jneuropsychiatry.org/peer-review/ventilatory-support-outcomes-in-amyotrophic-lateral-sclerosis-als-patients-12934.html
Ventilatory support (VS) has shown a valuable prognostic impact, even in bulbar-onset ALS. Thus, VS outcomes related to functional and phenotypic factors were analyzed in a cohort of ALS patients.Author: Bebiana Conde, Natalia Martins, Joao Carlos Winck
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589990/
Jun 21, 2019 · IV may be considered to preserve quality of life in patients with ALS who want long-term ventilatory support – – Termination of NIV/IV, end-of-life management: Discuss the options for respiratory support and end-of-life issues if the patient has dyspnea, other symptoms of …Author: Johannes Dorst, Albert C. Ludolph
https://www.cochrane.org/CD004427/NEUROMUSC_mechanical-ventilation-people-amyotrophic-lateral-sclerosismotor-neuron-disease
Oct 05, 2017 · Review question. Does mechanical ventilation improve the survival of people with amyotrophic lateral sclerosis (ALS)? How does it affect disease progression and quality of life, and does it have any unwanted effects? Background. Amyotrophic lateral sclerosis, also known as motor neuron disease, is a condition in which nerves that control movement are lost.
https://www.livescience.com/41669-device-delays-ventilator-need.html
Most ALS patients develop chronic hypoventilation over the course of their disease. Traditionally, we assist them with non-invasive ventilator support.Author: Dr. Stephen Kolb
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