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http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-2010&volume=3&issue=2&spage=117
Title: Acquired Carbapenem-Hydrolyzing Beta-Lactamases and their Genetic Support VOLUME: 3 ISSUE: 2 Author(s):L. Poirel and P. Nordmann Affiliation:Service de Bacteriologie-Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 LeKremlin-Bicetre Cedex, France Keywords:carbapenem, chbls, chbetals, imp-1, blaim-1, blasme-1 Abstract: Carbapenem-hydrolyzing ß-lactamases of …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186976/
A carbapenem-resistant Pseudomonas aeruginosa strain (PA41437) susceptible to expanded-spectrum cephalosporins was recovered from several consecutive lower-respiratory-tract specimens of a patient who developed a ventilator-associated pneumonia while hospitalized in an intensive care unit. Cloning experiments identified OXA-198, a new class D β-lactamase which was weakly related (less than 45 ...Cited by: 51
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC163693/
Naas T, Livermore DM, Nordmann P. Characterization of an LysR family protein, SmeR from Serratia marcescens S6, its effect on expression of the carbapenem-hydrolyzing beta-lactamase Sme-1, and comparison of this regulator with other beta-lactamase regulators.Cited by: 443
https://www.researchgate.net/publication/6969233_Characterization_of_acquired_b-lactamases_and_their_genetic_support_in_multidrug-resistant_Pseudomonas_aeruginosa_isolates_in_Taiwan_The_prevalence_of_unusual_integrons
Acquired beta-lactamases and their genetic support were determined by PCR-based strategies. Four and 16 of the 26 isolates were found to produce VIM-2 and VIM-3 metallo-beta-lactamases (MBLs),...
https://www.researchgate.net/publication/51458069_Carbapenems_Do_they_have_a_future
Carbapenems: Do they have a future. ... Acquired Carbapenem-Hydrolyzing Beta-Lactamases and their Genetic Support ... This review underlines the worldwide spread of carbapenem-hydrolyzing beta ...
https://www.sciencedirect.com/science/article/pii/S0196439908000251
Carbapenem-Hydrolyzing Beta-Lactamases. The carbapenem-hydrolyzing enzymes possess the most extensive substrate profiles of all β-lactamases and are increasingly clinically important β-lactamases (38). Chromosomal enzymes capable of hydrolyzing carbapenems have been recognized without causing undue concern for a long time, but the more ...Cited by: 18
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1234128/
Imipenem and meropenem are among the drugs of choice used to treat nosocomial infections due to multidrug-resistant Acinetobacter baumannii isolates. However, their efficacy is being increasingly compromised by the emergence of carbapenem-hydrolyzing β-lactamases of molecular Ambler class B (metalloenzymes) and D enzymes (oxacillinases) (1, 2, 3, 12, 17).Cited by: 148
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149323/
Carbapenems, which include the widely used antibiotics meropenem and imipenem, are used to treat severe infections caused by β-lactamase-harboring bacteria (1, 3).Unfortunately, as with other antibiotics, resistance to carbapenem antibiotics has emerged and several β-lactamases that catalyze the hydrolysis of carbapenems have been identified (9, 11).Cited by: 28
https://www.researchgate.net/publication/27800648_Imipenem_resistant_metallo_b_lactamse_producing_Pseudomonas_aeruginosa
beta-lactamases and their genetic support. Curr Pharma ... Carbapenem-hydrolyzing beta-lactamases of several Ambler molecular classes have been reported as the source of acquired beta …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310167/
Acquired resistance to expanded-spectrum cephalosporins has been reported in Klebsiella pneumoniae and is mainly related to the production of Ambler class A extended-spectrum β-lactamases (ESBLs) and plasmid-encoded AmpC cephalosporinases ().A few reports have described β-lactamase-mediated resistance to carbapenems in K. pneumoniae related to Ambler class B metalloenzymes, i.e., IMP-1 …Cited by: 853
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