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https://www.texasheart.org/heart-health/heart-information-center/topics/inotropic-agents/
Inotropic agents, or inotropes, are medicines that change the force of your heart's contractions. Positive inotropes strengthen the force of the heartbeat. Negative inotropes weaken the force of the heartbeat. Both kinds are used in the treatment of many different cardiovascular conditions.
https://academic.oup.com/bja/article/90/4/525/274464/
Apr 01, 2003 · Editor—We read with interest the article on the incidence, and risk calculation for utilisation, of inotropic support in patients undergoing cardiac surgery.1 The findings of the independent predictors of ventricular dysfunction (presence of chronic obstructive pulmonary disease, age >65 yr, aortic cross clamp time >90 min), would be of no ...Author: C. Weidmann, M. Herbertson, A. Jünger
https://www.drugs.com/drug-class/inotropic-agents.html
Most positive inotropes work by increasing the release of calcium from the sarcoplasmic reticulum or increasing the influx of calcium into the heart muscle cell. Initial monitoring of hemodynamic parameters such as cardiac output, arterial pressure, and central venous pressure is required on initiation of a positive inotrope.
https://ccforum.biomedcentral.com/articles/10.1186/cc3024
Dec 16, 2004 · Many adult patients require temporary inotropic support after cardiac surgery. We reviewed the literature systematically to establish, present and classify the evidence regarding choice of inotropic drugs. The available evidence, while limited in quality and scope, supports the following observations; although all β-agonists can increase cardiac output, the best studied β-agonist and the …Cited by: 141
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691094/
Dec 04, 2015 · The most common use of inotropes is among hospitalized patients with acute decompensated heart failure, with reduced left ventricular ejection fraction and with signs of end-organ dysfunction in the setting of a low cardiac output. Inotropes can be used in patients with severe systolic heart failure awaiting heart transplant to maintain ...Cited by: 30
https://www.thecardiologyadvisor.com/home/decision-support-in-medicine/cardiology/interventional-pharmacology-inotropes-and-vasopressors/
General (including evidence of efficacy) Inotropes and vasopressors Inotropes and/or vasopressors are essential in the management of cardiogenic shock complicating myocardial infarction/ischemia and in the treatment of hemodynamic instability occurring during coronary interventions. They help stabilize patients at risk for progressive hemodynamic collapse or serve as a life-sustaining bridge ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677728/
Several clinical studies have examined the factors associated with the development of LCOS and the subsequent need for inotropic support. 3–5 Commonly defined as low cardiac output (confidence interval [CI] <2.5) with evidence of end-organ dysfunction such as low urine output (<0.5mL/kg/hr), LCOS is associated with increased morbidity and ...Cited by: 15
https://www.uptodate.com/contents/inotropic-agents-in-heart-failure-with-reduced-ejection-fraction
May 25, 2018 · Therapy with these agents is of potential value only in patients with decreased cardiac contractility. Those with HF with preserved ejection fraction (HFpEF; also known as diastolic HF) do not need inotropic support, and the myocardial effects of these agents may be detrimental in such patients.
https://www.aci.health.nsw.gov.au/__data/assets/pdf_file/0009/306585/Inotropes_and_Vasoconstictor_Package.pdf
INOTROPE LEARNING PACKAGE 2014 3 S.Shunker (CNC) ICU Liverpool Hospital Cardiac output & its determinants CARDIAC OUTPUT (C.O) Cardiac output Is the amount of …
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