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http://www.lhsc.on.ca/Health_Professionals/LRCP/Oncology_Practice_Guidelines/LRCPGCSFalgorithmneutropeniaNov07.pdf
Algorithm for White Cell Growth Factor (G-CSF) Support Step 1. Evaluate patient for risk of febrile neutropenia (FN) ... *Dose Dense Chemotherapy1,4,5 *Standard Dose Chemo High Risk FN (>20%)1,4,5 • G-CSF secondary prophylaxis recommended if curative intent1,4 G-CSF primary prophylaxis recommended1,4 ...
https://www.medscape.com/viewarticle/540139_4
Oct 23, 2019 · Scheduling G-CSF Support With Dose-dense Chemotherapy . The timing and duration of G-CSF support are crucial to the optimal administration of dose-dense chemotherapy.
https://onlinelibrary.wiley.com/doi/full/10.1002/cncr.21400
Sep 21, 2005 · Vinorelbine and docetaxel are active single agents in the treatment of nonsmall cell lung carcinoma (NSCLC) and may provide enhanced activity when combined in a dose‐dense fashion. The efficacy and safety of this combination was assessed when it was administered every 14 days with Filgrastim support in a community practice setting.Cited by: 9
https://ascopubs.org/doi/abs/10.1200/jco.2015.33.15_suppl.561
561. Background: In randomized trials, administration of dose dense (dd) doxorubicin and cyclophosphamide (AC) followed by paclitaxel (T) with G-CSF support improved outcomes compared with every 3 week dosing in the adjuvant treatment of early breast cancer.However, the use of G-CSF in dd regimens is associated with increased cost and its utility for the T portion of this regimen is unclear.Author: Flavia Rocha Paes, Ines Maria Vaz Duarte Luis, Rafael Brant Costa, Otto Metzger Filho, Melissa E Hug...
https://link.springer.com/article/10.1007/s10549-008-0152-9
Aug 27, 2008 · Purpose Granulocyte-colony stimulating factor (G-CSF) was used in CALGB 9741 to support dose-dense sequential chemotherapy with doxorubicin and cyclophosphamide (AC) followed by paclitaxel (P) (Citron et al. J Clin Oncol 21:1431–1439, 2003). However, myelosuppression is not known to be dose or schedule limiting for paclitaxel.Cited by: 12
https://clinicaltrials.gov/ct2/show/NCT02698891
This research study is testing the safety and feasibility of delivering the 4 cycles of 'dose-dense' paclitaxel without the use of Neulasta (Pegfilgrastim) as a Granulocyte Colony-stimulating Factor (G-CSF) support.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846279/
Feb 27, 2010 · G-CSF prophylaxis is now recommended when the overall risk of febrile neutropenia (FN) due to regimen and individual patient factors is ≥20%, for supporting dose-dense and dose-intense chemotherapy and to help maintain dose density where dose reductions have been shown to compromise outcomes.Cited by: 93
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064124/
Feb 10, 2005 · The every 2 weeks schedule was delivered with granulocyte colony-stimulating factor (CSF) support. This trial is particularly informative because it was a pure test of the dose density concept; all patients received the same drugs, the same number of drug cycles, at the same cumulative dose and the same individual doses, in all arms of the trial.Cited by: 59
http://chemocare.com/chemotherapy/drug-info/g-csf.aspx
Chemocare.com uses generic names in all descriptions of drugs. Neupogen, Granix and Zarxio are trade names for filgrastim. Granulocyte - colony stimulating factor (G-CSF) is another name for filgrastim. In some cases, health care professionals may use the trade name Neupogen, Granix or Zarxio when referring to the generic drug name filgrastim.
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