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https://cshperspectives.cshlp.org/content/8/1/a020479.full
Jun 22, 2015 · METABOLIC SUPPORT OF AXON FUNCTION. Once myelination is completed, the developmentally important cytosolic channels decrease in size, but remain as a significant compartment of (noncompacted) myelin, which can be visualized, for example, by dye injections, the expression of fluorescent proteins , or high-pressure freezing EM.Cited by: 198
https://europepmc.org/articles/PMC4691794
Jun 22, 2015 · However, unlike in the peripheral nervous system (PNS), in which neuregulin-1 on the axonal membrane controls myelination by Schwann cells, an equivalent single-key regulator that triggers myelination by oligodendrocytes in the CNS has not been identified.
https://cshperspectives.cshlp.org/content/8/1/a020479.short
Jun 22, 2015 · Oligodendrocytes are metabolically active and functionally connected to the subjacent axon via cytoplasmic-rich myelinic channels for movement of macromolecules to and from the internodal periaxonal space under the myelin sheath.Cited by: 198
http://cshperspectives.cshlp.org/content/8/1/a020479.full.pdf
Oligodendrocytes: Myelination and Axonal Support Mikael Simons1,2 and Klaus-Armin Nave3 1Cellular Neuroscience, Max Planck Institute of Experimental Medicine, 37075 Go¨ttingen, Germany 2Department of Neurology, University of Go¨ttingen, 37075 Go¨ttingen, Germany 3Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Go¨ttingen, Germany
https://www.researchgate.net/publication/279309038_Oligodendrocytes_Myelination_and_Axonal_Support
Oligodendrocytes: Myelination and Axonal Support. ... Model showing the direction of how myelin wraps around the axon. There are two motions: the wrapping of the leading edge at the inner tongue ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613737/
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term axonal integrity 1–3. However, the underlying support mechanisms are not understood 4. Here we identify ametabolic component of axon–glia interactions by generating conditional Cox10 (protoheme IX farnesyltransferase) mutant mice, in which oligodendrocytes and Schwann cells fail to assemble stable mitochondrial cytochrome c oxidase (COX, also known as mitochondrial …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669561/
Sep 01, 2017 · Alternatively, promoting specific changes in the expression of the genes involved in oligodendrocyte axonal support could also affect oligodendrocyte energy homeostasis and in turn promote the maintenance of the myelin sheath, which would therefore not impede the flow of trophic support from oligodendrocyte to neuron.Cited by: 58
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556025/
Sep 01, 2015 · Oligodendrocytes in CNS Myelination. From start to finish, the life of an OL is defined by four distinct phases: (1) the birth, migration, and proliferation of oligodendrocyte precursor cells (OPCs), a process occurring in waves, followed by (2) morphological differentiation – the OL establishes an expansive network of processes, (3) axonal contact, leading to ensheathment and generation of ...Cited by: 27
https://www.ncbi.nlm.nih.gov/pubmed/12590258
Myelination of axons by oligodendrocytes enables rapid impulse propagation in the central nervous system. But long-term interactions between axons and their myelin sheaths are poorly understood. Here we show that Cnp1, which encodes 2',3'-cyclic nucleotide phosphodiesterase in oligodendrocytes, is essential for axonal survival but not for myelin assembly.Cited by: 871
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