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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691094/
Dec 04, 2015 · Use of inotropic drugs is associated with risks and adverse events. This review will discuss the use of the inotropes digoxin, dopamine, dobutamine, norepinephrine, milrinone, levosimendan, and omecamtiv mecarbil. Long-term inotropic therapy …Cited by: 30
https://www.uptodate.com/contents/inotropic-agents-in-heart-failure-with-reduced-ejection-fraction
May 25, 2018 · Those with HF with preserved ejection fraction (HFpEF; also known as diastolic HF) do not need inotropic support, and the myocardial effects of these agents may be detrimental in such patients. The efficacy of acute intravenous inotropic support is well established in patients with severe myocardial systolic dysfunction.
https://www.drugs.com/drug-class/inotropic-agents.html
Inotropic agents are a group of medicines that affect the contraction of the heart muscle. Technically, inotropes can be divided into positive inotropes, which stimulate and increase the force of contraction of the heart muscle, and negative inotropes, which weaken the force of muscular contractions, decreasing how hard the heart has to work.
https://healthjade.net/inotropic/
Dobutamine, the most commonly used inotropic agent worldwide, is a non-selective β1- and β2-adrenergic receptor agonist with variable activities on the α1 receptor 9). Prevalent β1- and β2-adrenergic receptor activation results in reduced afterload and increased stroke volume, heart rate and cardiac output at low doses.
https://www.ncbi.nlm.nih.gov/books/NBK470431/
Dobutamine can reasonably be given in continuous intravenous form for inotropic support to bridge patients with late-stage heart failure, stage D, that is refractory to guideline-directed medical therapy until patients who are candidates for and awaiting cardiac transplantation or mechanical circulatory support receive the appropriate long-term ...
https://www.thecardiologyadvisor.com/home/decision-support-in-medicine/cardiology/interventional-pharmacology-inotropes-and-vasopressors/
Dobutamine is a synthetic catecholamine that stimulates beta-1 and beta-2 adrenergic receptors, but has little action on alpha-receptors. It has potent inotropic activity with only modest chronotropic effect. Dobutamine increases stroke volume and cardiac output, and lowers pulmonary capillary wedge pressure and systemic vascular resistance.
https://ccforum.biomedcentral.com/articles/10.1186/cc3024
Dec 16, 2004 · Many adult patients require temporary inotropic support after cardiac surgery. We reviewed the literature systematically to establish, present and classify the evidence regarding choice of inotropic drugs. The available evidence, while limited in quality and scope, supports the following observations; although all β-agonists can increase cardiac output, the best studied β-agonist and the …Cited by: 141
https://www.drugs.com/pro/dobutamine.html
Jun 29, 2005 · Dobutamine Injection, USP is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of adults with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.
https://www.texasheart.org/heart-health/heart-information-center/topics/inotropic-agents/
Inotropic agents, or inotropes, are medicines that change the force of your heart's contractions. Positive inotropes strengthen the force of the heartbeat. Negative inotropes weaken the force of the heartbeat. Both kinds are used in the treatment of many different cardiovascular conditions.
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